I've 'rebirthed' about a dozen XP machines over the past 12 months, mostly 'Pro', and only had one kick up a fuss on activation.
'Rebirthing' is the process whereby an office-leased machine is returned to the store to be resold as second-hand, needing the drive wiped and the OS re-installed. Each has the reg 'sticker' attached, so the number is not a problem [except when it's poorly printed....8 = B , etc].
One IBM desktop machine didn't like the disk used to install the OS [I'd used the same on all] so on activation the comp popped up a 'call MS' message....but with a fair understanding of Indian-flavoured English it was soon sorted.
One 'hopes' that wasn't included in the 'Invalids' as it really had more to do with a crappy printing of the label than anything else...