This may be minor, but I think every game I've gotten Bacco and Ascian as quests. While I enjoy them, it gets old doing them in every game. Maybe the "Bacco" champion could at least be a randomized available champion from the champion table?
Ascian is also getting a bit old because the quest is essentially the same. If the player gets to end up with Ascian every game, it defeats the purpose a bit.
The Alchemy quest also suffers from this--you end up threatening the "thug" and he just says "I had to try." The first time this is cute, but on repetitive play sessions it is meaningless. He has never attacked me--is there ever an instance where he will?
There may be other quests that suffer from similar pitfalls, but I think some minor tweaks could make questing more enjoyable.