Point one, the races aren't balanced. If you choose to play as the Narn, buckle, up.
Point two, there is still debate if the Vorlon and Shadow's should be NPC only... but we've done some wonky things so the AI can't play them well either (cheats aside).
Point three, fighters in some instances will end up in a perpetual tail chase. This is resolved by fighter decay if the carrier can be destroyed. This also leads to some rather odd behavior from ships with anti-fighter weapons. Most battles it isn't too bad but occasionally its Outer Limits strange. (A lot of work has been done to mitigate this and still represent the tech disparities. Vanilla resolved the AI issues by giving strike craft insane tactical speeds.)
Point four, know your weapon arcs.
Point five, some ships are particularly sluggish early game, see point one.
There's more but why spoil the fun.