Upon further testing I also determined that at times when the mouse cursor attempts to leave the bottom right corner of Monitor 1 it will often transit to AWM18(3) bottom left monitor, which essentially jumps the gap under AWM18(2) and continues through AWM18(3).
Why this is frustrating is that the Windows messaging, system clock etc. are located in the bottom right corner of Monitor 1 and just touching the edge of the monitor boundary will send the mouse cursor elsewhere.