I already keep a good eye on all autostart programs. I have no adware or spyware, as indicated by various scans. All of the software I have installed is from reputable houses, no back street specials. That's not to say there can't be any bugs, but it is unlikely.
By the way, under Windows 8.1, MSCONFIG no longer provides a means of changing the startup programs; it's now done from Task Manager.