2 - Disruption Matrix
2 - Furious Defense
4 - Group Shield (at level 4 this gets you 83% damage reduction)
2 - Inspire and Impair (this is an awesome ability: lvl 1: 50% weapon cooldown increase for enemy ships in the grav well, -50% for your ships. lvl 2: 100% cooldown increase for enemy ships, -75% for your ships)
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2 - Health/shields
4 - Weapons
2 - Anti-Matter
The most important abilities for the TL titan are, IMO, Group Shield and Inspire and Impair. Both give your fleet a huge advantage in pretty much any battle. 4 points in the weapons upgrade makes it actually do a reasonable amount of damage. With 2 in Furious Defense and 2 in Health/Shields it is tough enough to stand up to an awful lot of punishment. Sometimes I put 4 in Furious Defense and 0 in Disruption Matrix, depending on what I'm facing.
Edit: Sorry, the last part is backwards. Should be: Sometimes I put 0 in Furious Defense and 4 in Disruption Matrix, depending on what I'm facing.