Honestly the Vasari Rebel Titan has amasing synergy with its first, third and last powers. Nano Leach is what the entire best hinges on getting as guickly as possible. I mean sure the Channel for the Second ability is great and all, but really if your running it with a fleet then, it is best suited like the Anklyon, in the middle of the fight where you get the maximum output from NL then you combo off a Gravity Bomb for a "Nope you can't" moment or even Sever which in of itself is a great ability. Play this card in the middle of a massive fleet fight and you are sure to win, if it is supported well, I ran two Desolators and a Antorak Maurader with her, and a host of small "chump ships" I took on two pirate bases and three massive AI fleets and barely lost half my fleet.
Synergy wise: Vasari are the Strongest; they may not have the Armor or Weapons to tackle larger entities, but their vessels syngerist reactions to even the capital ships around them, make them a viable threat in any engagement.
I am about to test another theory I have, and it is based off of the Advent Rebels Eradica, I think with the right fleet build with an Eradica, you can take on mulitple OPs without worrying about too much.
PP (PhyrexianPraetor- Steam)
Hit me up if you want to play.