I use hotkeys for lots of things...ie, the diplomacy screen, the research screen, the black market screen, to pull up all 3 ship build menus, to pull open the planetary upgrade menu, and also the logistics and the tactical upgrade and build menus.
Of course, I also have a Merc Stealth keyboard with a 35 key keypad that fits my left hand and I have mapped all of the applicable keys to that.
I also map "Squad Locks" to my number keys 1-0, for easier and quicker access to a group of fleets.